CD Genomics provides viral genome sequencing services under the Illumina and PacBio platforms. We can generate high quality, high data quality de novo assemblies from large viral genomes at a relatively low cost.
Viruses are the most abundant biological entities on Earth that significantly affect organisms by causing disease and altering their immune systems. Despite this proximity and influence, less than 0.01% of viruses are sequenced. Research into viral infections and the development of new therapies have now made great strides in etiopathogenetic.
Another widely used NGS platform: Illumina recommends a maximum length of 300-500 nucleotides per sequence analysis. Recently, Pac Bío has improved sequencing technology with real-time single-molecule sequencing. Here you will find incorrectly filled long reads that exceed the limits of NGS.
The CD genome platform has great potential for viral genome sequencing. Extensive viral sequences will provide reference genomes for predicting viral diversity, ecology, adaptation and evolution, as well as emerging viral infectious diseases.
Replication in the nucleus of host cells (except Poxviridae which have their own DNA-dependent RNA polymerase).
No reverse transcriptase (almost all viruses): Negative-sense viral DNA is transcribed into mRNA using host cell RNA polymerase → viral proteins and dsDNA progeny are produced.
with reverse transcriptase
Hepadnavirus (HBV only, reverse transcription virus)
Translation
DNA origin
Requires RNA-dependent DNA polymerase
(Acts like a reverse transcriptase)
Viral mRNA → viral protein synthesis → HBV RNA-dependent DNA polymerase then transcribes the viral RNA to form progeny DNA.
Viral genomes are among the fastest-evolving organisms in biology due to their short replication time and release of large numbers of genes per replication cycle. Evolution occurs through several mechanisms, including random mutation, recombination, recombination, and gene amplification/reduction. Leads to parasites and defective interfering genomes
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